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Diflucan is used to treat vaginal, oral, and esophageal fungal infections caused by Candida; urinary tract infections, peritonitis, pneumonia and disseminated infections caused by Candida; cryptococcal meningitis; and to prevent Candida infections in patients treated with. It is like a mutant yeast that takes multiple visits to get rid of. There’s no oral equivalent to Diflucan that you can get over the counter. Whooping cough Nystatin lozenges (pastilles) should be held in the mouth and allowed to dissolve slowly and completely. Note – the treatment must be continued for 14 days. No: Although many antifungal drugs are available over-the-counter (otc), Nystatin products are available by prescription only. But ask for additional steroid cream or it will come back over and over again. Also, it does not pass through the intestinal walls, thus, it remains in the intestines at maximum concentration. 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