Tasigna medication guide
Tasigna medication guide
II Nilotinib (Tasigna) is a second-generation BCR-ABL kinase inhibitor, recently introduced and used for the treatment of chronic or accelerated phase CML patients, intolerant or resistant to imatinib. 2) • Avoid food 2 hours before and 1 hour after taking the dose. TASIGNA is indicated for the treatment of pediatric patients greater than or equal to 1 year of age with CP and AP Ph+ CML with resistance or intolerance to prior tyrosine kinase inhibitor (TKI) therapy. TASIGNA doses should be taken approximately 12 hours apart. Dosage in Adult Patients with Newly Diagnosed Ph+ CML-CP. The National Cancer Comprehensive Network (NCCN) recommends the use of Tasigna for primary or follow-up CML therapy in all stages. Therefore, Tasigna may alter serum concentration of other drugs (7. Tasigna can cause a possible life-threatening heart problem called QTc prolongation. Nilotinib General Indications Action Pharmacokinetics Contraindication / Precautions Adverse Reactions / Side Effects Interactions Route / Dosage Availability. Nilotinib (Tasigna) is a second-generation BCR-ABL kinase inhibitor, recently introduced and used for the treatment of chronic or accelerated phase CML patients, intolerant or resistant to imatinib. Side effects In addition to its desired action, this medication may cause some side effects, notably:. It is best taken on an empty stomach, one hour before or 2 hours after a meal. 97 for 120 capsules 150 mg Tasigna oral capsule tasigna medication guide from ,491. One of the most important things to know about taking TASIGNA is that it should never be taken with food. It may also induce CYP2B6, CYP2C8 and CYP2C9. This Medication Guide summarizes the most important information about Tasigna If you would like more information, talk with your doctor. This guide to the dosing and administration of TASIGNA has been developed as part of a plan to help reduce the risk of serious adverse reactions and maximize the benefit-risk profile of TASIGNA. Important: Follow the instructions on the label. Take Tasigna on an empty stomach. Coadministration of certain drugs may need to be avoided or dosage adjustments may be necessary; review drug interactions. They offer a guide to coverage and are not intended to dictate to providers how to practice medicine. If you would like more information, talk with your doctor. The purpose of this brochure is to ensure tasigna medication guide that health care professionals prescribing TASIGNA Understand specific drug-drug interactions, drug-food. Tasigna should be taken twice daily approximately 12 hours apart and must not be taken with food. Providers are expected to exercise their medical judgement in providing the most appropriate care for their patients The recommended dose of Tasigna is 400 mg twice daily (see section CLINICAL STUDIES). Tasigna is usually taken every 12 hours. NCCN also recommends Tasigna for the treatment of the following: progressive gastrointestinal stromal tumors (GIST) when patient is no longer receiving benefit from Gleevec®(imatinib), Stivarga®. Temporary interruption of therapy and/or a dosage reduction may be necessary in patients who develop toxicity or intolerable side effects Tasigna comes in capsule form. Adult Patients With Resistant or Intolerant Ph+ CML-CP and CML-AP. The recommended dosage of Tasigna is 300 mg orally twice daily This Tasigna price guide is based on using the Drugs. Food can increase your blood levels of nilotinib and may increase harmful side effects This Medication Guide summarizes the most important information about Tasigna If you would like more information, talk with your doctor. Page 3 of 6 Criteria for continuation of coverage (renewal request): Tasigna (nilotinib) is considered. The hard capsules should be swallowed whole with water. It binds to and stabilizes the inactive conformation of the kinase domain of Abl protein. 23 for 28 capsules Important: When there is a range of pricing, consumers should normally expect to pay the lower price Clinical Pharmacy Program Guidelines for Tasigna. 1) CYP3A4 inducers may affect serum concentration (7. 2) Tasigna is an inhibitor of CYP3A4, CYP2C8, CYP2C9, and CYP2D6. General information about Tasigna. This Medication Guide summarizes the most important information about Tasigna. tasigna medication guide